Sensory processing sensitivity is a recently proposed construct referring to a tendency to process a variety of information more strongly and deeply than others. Although some research has found links between sensory processing sensitivity and psychological difficulties, highly sensitive people may not necessarily be predisposed to negative affect, but may be more sensitive to poor parenting. Two hundred thirteen college students were given a measure of sensory processing sensitivity (the HSPS), the parental bonding scale (measuring parental care and over-protection), the trait anxiety scale, and the Beck depression inventory. Sensory processing sensitivity predicted both anxiety and depression above and beyond parental factors, indicating that it may be an independent risk factor. An interaction was found between sensory processing sensitivity and parental care when measuring depression. Highly sensitive people may be particularly sensitive to uncaring parents. Results indicate that sensory processing sensitivity may be a temperamental disposition that interacts meaningfully with environmental factors.