The aim of this study was to examine the relationship between sensory processing sensitivity, personality dimensions and mental health. In a sample of University of Mohaghegh Ardabili students. One hundred and eighty students were included in this study. All participants were asked to complete the highly sensitive person scale, NEO-five factor inventory and general health questionnaire. Analysis of the data involved both descriptive and inferential statistics including means, standard deviations, Pearson’s correlation coefficients and regression analysis. The results revealed that ease of excitation was positively correlated to neuroticism and mental health (physical problems, anxiety, disorder in social functioning and depression) and negatively related to extra version. Aesthetic sensitivity was positively related to neuroticism, openness to experience, consienciousness and anxiety. Low sensory threshold was also positively related to neuroticism, physical problems, anxiety and mental health. The results of regression analysis revealed that sensory processing sensitivity can explain considerable variances of personality traits and mental health.